In the 1950s, the CIA launched Project MKUltra, in which they experimented with LSD as a possible truth serum, mind control drug, or biological weapon. The head of the project was biochemist Dr. Sidney Gottlieb, who has been compared to "Q" from the James Bond movies as well as a mad scientist. The project began with volunteers, but then moved to unwitting subjects, with nefarious results that you can read about in this Neatorama post.
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